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The most common disease of GH surplus is a pituitary gland consisting of somatotropic cells in the front pituitary gland. These somatotropic adenomas are benign and grow slowly and gradually produce more and more GH. For years, the main clinical problems are GH gains. Finally, the adenoma may become large enough to cause a headache, weaken vision by pressure on optic nerve or cause lack of other pituitary hormones by displacement.