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The most common disease of GH surplus is a pituitary gland consisting of somatotropic cells in the front pituitary gland. These somatotropic adenomas are benign and grow slowly and gradually produce more and more GH. For years, the biggest clinical problems are the GH surpluses. Finally, the adenoma may become large enough to cause a headache, impair vision by pushing on the optical nerves or causing a lack of other pituitary hormones by displacement.

Prolonged GH excess consumes the legs, fingers, and toes of the leg. The result of the weight of the jaw and an increased number of sizes is called acromegaly. The accompanying problems may include sweating, nerve pressure (eg carpal tunnel syndrome), muscle weakness, excess hormone binding globulin (SHBG), insulin resistance or even a rare type of type 2 diabetes and decreased sexual function.

It is extremely rare for such a tumor to occur in childhood, but when it does, excessive GH can cause excessive growth, which is traditionally called pituitary gigantism.

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